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hyperion helios imaging mass cytometry platform  (fluidigm)


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    Structured Review

    fluidigm hyperion helios imaging mass cytometry platform
    ( A ) Patient-matched primary, synchronous metastasis, and recurrent metastasis HGSOC samples from 42 patients were assembled into a TMA. The Kaplan-Meier survival curve below shows the time to relapse, with patients classified as early or late relapse (<15 or >15 months to relapse, respectively). Scale bars, 4 mm. ( B ) Imaging mass <t>cytometry</t> was performed by staining the tissue with metal ion–tagged antibodies, ablating the tissue, and performing image data analysis. ( C ) Three major cell types and their protein expression patterns are shown in sample IMC images and a heatmap: immune cells, fibroblasts, and epithelial (cancer) cells. Scale bar, 25 μm. ( D ) Cell composition of (regions of interest) ROIs was approximately 50 to 55% epithelial cancer cells, 25 to 30% fibroblasts, and 15 to 20% immune cells in primary, synchronous metastasis, and recurrence tumor types. ( E ) Lymph node metastases contained elevated levels of immune cells, P = 1.1 × 10 −5 , analysis of variance (ANOVA). ( F ) Early and late relapse conditions were associated with similar proportions of immune cells, fibroblasts, and epithelial cells. Stacked bar plots are shown to illustrate the summation to 1, error bars denote SD, and the error bar is single-sided to reduce visual clutter. Cell proportion differences are not statistically significant by ANOVA unless noted with *.
    Hyperion Helios Imaging Mass Cytometry Platform, supplied by fluidigm, used in various techniques. Bioz Stars score: 93/100, based on 1523 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hyperion helios imaging mass cytometry platform/product/fluidigm
    Average 93 stars, based on 1523 article reviews
    hyperion helios imaging mass cytometry platform - by Bioz Stars, 2026-05
    93/100 stars

    Images

    1) Product Images from "Spatiotemporal architecture of immune cells and cancer-associated fibroblasts in high-grade serous ovarian carcinoma"

    Article Title: Spatiotemporal architecture of immune cells and cancer-associated fibroblasts in high-grade serous ovarian carcinoma

    Journal: Science Advances

    doi: 10.1126/sciadv.adk8805

    ( A ) Patient-matched primary, synchronous metastasis, and recurrent metastasis HGSOC samples from 42 patients were assembled into a TMA. The Kaplan-Meier survival curve below shows the time to relapse, with patients classified as early or late relapse (<15 or >15 months to relapse, respectively). Scale bars, 4 mm. ( B ) Imaging mass cytometry was performed by staining the tissue with metal ion–tagged antibodies, ablating the tissue, and performing image data analysis. ( C ) Three major cell types and their protein expression patterns are shown in sample IMC images and a heatmap: immune cells, fibroblasts, and epithelial (cancer) cells. Scale bar, 25 μm. ( D ) Cell composition of (regions of interest) ROIs was approximately 50 to 55% epithelial cancer cells, 25 to 30% fibroblasts, and 15 to 20% immune cells in primary, synchronous metastasis, and recurrence tumor types. ( E ) Lymph node metastases contained elevated levels of immune cells, P = 1.1 × 10 −5 , analysis of variance (ANOVA). ( F ) Early and late relapse conditions were associated with similar proportions of immune cells, fibroblasts, and epithelial cells. Stacked bar plots are shown to illustrate the summation to 1, error bars denote SD, and the error bar is single-sided to reduce visual clutter. Cell proportion differences are not statistically significant by ANOVA unless noted with *.
    Figure Legend Snippet: ( A ) Patient-matched primary, synchronous metastasis, and recurrent metastasis HGSOC samples from 42 patients were assembled into a TMA. The Kaplan-Meier survival curve below shows the time to relapse, with patients classified as early or late relapse (<15 or >15 months to relapse, respectively). Scale bars, 4 mm. ( B ) Imaging mass cytometry was performed by staining the tissue with metal ion–tagged antibodies, ablating the tissue, and performing image data analysis. ( C ) Three major cell types and their protein expression patterns are shown in sample IMC images and a heatmap: immune cells, fibroblasts, and epithelial (cancer) cells. Scale bar, 25 μm. ( D ) Cell composition of (regions of interest) ROIs was approximately 50 to 55% epithelial cancer cells, 25 to 30% fibroblasts, and 15 to 20% immune cells in primary, synchronous metastasis, and recurrence tumor types. ( E ) Lymph node metastases contained elevated levels of immune cells, P = 1.1 × 10 −5 , analysis of variance (ANOVA). ( F ) Early and late relapse conditions were associated with similar proportions of immune cells, fibroblasts, and epithelial cells. Stacked bar plots are shown to illustrate the summation to 1, error bars denote SD, and the error bar is single-sided to reduce visual clutter. Cell proportion differences are not statistically significant by ANOVA unless noted with *.

    Techniques Used: Imaging, Mass Cytometry, Staining, Expressing



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    hyperion helios imaging mass cytometry platform  (fluidigm)
    93
    fluidigm hyperion helios imaging mass cytometry platform
    ( A ) Patient-matched primary, synchronous metastasis, and recurrent metastasis HGSOC samples from 42 patients were assembled into a TMA. The Kaplan-Meier survival curve below shows the time to relapse, with patients classified as early or late relapse (<15 or >15 months to relapse, respectively). Scale bars, 4 mm. ( B ) Imaging mass <t>cytometry</t> was performed by staining the tissue with metal ion–tagged antibodies, ablating the tissue, and performing image data analysis. ( C ) Three major cell types and their protein expression patterns are shown in sample IMC images and a heatmap: immune cells, fibroblasts, and epithelial (cancer) cells. Scale bar, 25 μm. ( D ) Cell composition of (regions of interest) ROIs was approximately 50 to 55% epithelial cancer cells, 25 to 30% fibroblasts, and 15 to 20% immune cells in primary, synchronous metastasis, and recurrence tumor types. ( E ) Lymph node metastases contained elevated levels of immune cells, P = 1.1 × 10 −5 , analysis of variance (ANOVA). ( F ) Early and late relapse conditions were associated with similar proportions of immune cells, fibroblasts, and epithelial cells. Stacked bar plots are shown to illustrate the summation to 1, error bars denote SD, and the error bar is single-sided to reduce visual clutter. Cell proportion differences are not statistically significant by ANOVA unless noted with *.
    Hyperion Helios Imaging Mass Cytometry Platform, supplied by fluidigm, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hyperion helios imaging mass cytometry platform/product/fluidigm
    Average 93 stars, based on 1 article reviews
    hyperion helios imaging mass cytometry platform - by Bioz Stars, 2026-05
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    ( A ) Patient-matched primary, synchronous metastasis, and recurrent metastasis HGSOC samples from 42 patients were assembled into a TMA. The Kaplan-Meier survival curve below shows the time to relapse, with patients classified as early or late relapse (<15 or >15 months to relapse, respectively). Scale bars, 4 mm. ( B ) Imaging mass cytometry was performed by staining the tissue with metal ion–tagged antibodies, ablating the tissue, and performing image data analysis. ( C ) Three major cell types and their protein expression patterns are shown in sample IMC images and a heatmap: immune cells, fibroblasts, and epithelial (cancer) cells. Scale bar, 25 μm. ( D ) Cell composition of (regions of interest) ROIs was approximately 50 to 55% epithelial cancer cells, 25 to 30% fibroblasts, and 15 to 20% immune cells in primary, synchronous metastasis, and recurrence tumor types. ( E ) Lymph node metastases contained elevated levels of immune cells, P = 1.1 × 10 −5 , analysis of variance (ANOVA). ( F ) Early and late relapse conditions were associated with similar proportions of immune cells, fibroblasts, and epithelial cells. Stacked bar plots are shown to illustrate the summation to 1, error bars denote SD, and the error bar is single-sided to reduce visual clutter. Cell proportion differences are not statistically significant by ANOVA unless noted with *.

    Journal: Science Advances

    Article Title: Spatiotemporal architecture of immune cells and cancer-associated fibroblasts in high-grade serous ovarian carcinoma

    doi: 10.1126/sciadv.adk8805

    Figure Lengend Snippet: ( A ) Patient-matched primary, synchronous metastasis, and recurrent metastasis HGSOC samples from 42 patients were assembled into a TMA. The Kaplan-Meier survival curve below shows the time to relapse, with patients classified as early or late relapse (<15 or >15 months to relapse, respectively). Scale bars, 4 mm. ( B ) Imaging mass cytometry was performed by staining the tissue with metal ion–tagged antibodies, ablating the tissue, and performing image data analysis. ( C ) Three major cell types and their protein expression patterns are shown in sample IMC images and a heatmap: immune cells, fibroblasts, and epithelial (cancer) cells. Scale bar, 25 μm. ( D ) Cell composition of (regions of interest) ROIs was approximately 50 to 55% epithelial cancer cells, 25 to 30% fibroblasts, and 15 to 20% immune cells in primary, synchronous metastasis, and recurrence tumor types. ( E ) Lymph node metastases contained elevated levels of immune cells, P = 1.1 × 10 −5 , analysis of variance (ANOVA). ( F ) Early and late relapse conditions were associated with similar proportions of immune cells, fibroblasts, and epithelial cells. Stacked bar plots are shown to illustrate the summation to 1, error bars denote SD, and the error bar is single-sided to reduce visual clutter. Cell proportion differences are not statistically significant by ANOVA unless noted with *.

    Article Snippet: Data were acquired on the Hyperion/Helios Imaging Mass Cytometry platform (Fluidigm/Standard BioTools) at the Cedars Sinai Spatial Molecular Profiling Shared Resource.

    Techniques: Imaging, Mass Cytometry, Staining, Expressing